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pMRI

Parametric MRI

Parametric MRI (pMRI) is a “spiritual successor” to CHOP-fMRU.

The purpose of this software is to provide access to powerful, fast and easy to use tools for various medical imaging post processing techniques including fMRU, T2/T2* mapping with built in LIC conversion, T1 mapping, 3D region growing, T2* perfusion, DWI, Dual Energy CT, Renal Scintigraphy and others.  pMRI fully integrates with PACS and runs on Microsoft Windows.  The software is currently in open beta and is available for download in the downloads section.  Please use the contact form below if you would like more information.

Features

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fMRU

Calculate split function and volumes.  Generate enhancement, patlak and excretion curves, histograms and much more!  This is CHOP-fMRU version 2.

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Segmentation

Segment images using various tools, ranging from free-hand to advanced region growing.  Threshold based on multiple parameters and more.

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DWI Analysis

Calculate ADC based on linear and non-linear exponential fits.  Estimate perfusion using bi-exponential modeling.  Generate virtual b-values.

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T1 Mapping

Generate inversion recovery curves from T1 MOLLI data.  Calculate mean T1 values, maps and histograms using non-linear least square fitting.

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MAG3

Analyze multi-phase renal scintigraphy studies for split function.  Threshold/region grow based on counts and generate various curves and histograms

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DICOM Support

Import/export DICOM studies and maintain them in a searchable database for quick and easy access.  Anonymize multiple studies with two clicks.

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Batch Processing

Save your analysis with one key stroke and analyze multiple cases in bulk after.  Copy and paste the results directly into excel, avoiding organizational errors.

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T2* Perfusion

Generate dynamic ΔR2* maps and ΔR2* vs time curves and histograms.  Calculate CBV values and maps based on a gamma variate fit.

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T2/T2* Mapping

Calculate mean T2/T2* values and maps with built in LIC conversion for R2/R2* liver iron data.  Includes mono and bi-exponential modeling as well as custom weighted fits.

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PACS Integration

Setup and connect to multiple servers.  Search, send and receive DICOM images over a network.  Integrates with common DICOM networking software. 

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Histograms

Generate histograms of various parameters.  Calculate means, standard deviations, and do Gaussian fits.  View dynamic histograms in real time.

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3D Rendering

Generate up to 8 independent surfaces per analysis.  Rotate the images with the mouse and move the camera around freely in real time!

Features
pMRI
Videos

Publications

Reference values for MRI‐derived psoas and paraspinal muscles and macroscopic fat infiltrations in paraspinal muscles in children

Marunowski, Kacper, Dominik Świętoń, Włodzimierz Bzyl, Małgorzata Grzywińska, Piotr Bandosz, Dmitry Khrichenko, and Maciej Piskunowicz. "Reference values for MRI‐derived psoas and paraspinal muscles and macroscopic fat infiltrations in paraspinal muscles in children." Journal of Cachexia, Sarcopenia and Muscle (2022).

The role of apparent diffusion coefficient histogram metrics for differentiating pediatric medulloblastoma histological variants and molecular groups

Gonçalves, Fabrício Guimarães, Luis Octavio Tierradentro-Garcia, Jorge Du Ub Kim, Alireza Zandifar, Adarsh Ghosh, Angela N. Viaene, Dmitry Khrichenko, Savvas Andronikou, and Arastoo Vossough. "The role of apparent diffusion coefficient histogram metrics for differentiating pediatric medulloblastoma histological variants and molecular groups." Pediatric Radiology (2022): 1-15.

Feasibility of T2 Mapping of the Sacroiliac Joints in Healthy Control Subjects and Children and Young Adults with Sacroiliitis

Francavilla, Michael L., Suraj D. Serai, Timothy G. Brandon, David M. Biko, Dmitry Khrichenko, Jie C. Nguyen, Rui Xiao, Nancy A. Chauvin, Liya Gendler, and Pamela F. Weiss. "Feasibility of T2 Mapping of the Sacroiliac Joints in Healthy Control Subjects and Children and Young Adults with Sacroiliitis." ACR open rheumatology 4, no. 1 (2022): 74-82.

Application of Apparent Diffusion Coefficient Histogram Metrics for Differentiation of Pediatric Posterior Fossa Tumors

Gonçalves, Fabrício Guimarães, Alireza Zandifar, Jorge Du Ub Kim, Luis Octavio Tierradentro-García, Adarsh Ghosh, Dmitry Khrichenko, Savvas Andronikou, and Arastoo Vossough. "Application of Apparent Diffusion Coefficient Histogram Metrics for Differentiation of Pediatric Posterior Fossa Tumors." Clinical Neuroradiology (2022): 1-12.

Rate of Change of Liver Iron Content by MR Imaging Methods: A Comparison Study

Venkatakrishna, Shyam Sunder B., Hansel J. Otero, Adarsh Ghosh, Dmitry Khrichenko, and Suraj D. Serai. "Rate of Change of Liver Iron Content by MR Imaging Methods: A Comparison Study." Tomography 8, no. 5 (2022): 2508-2521.

Can Ultrasound-Guided Xenon Delivery Provide Neuroprotection in Traumatic Brain Injury?

Hwang, Misun, Rajarshi Chattaraj, Anush Sridharan, Samuel S. Shin, Angela N. Viaene, Sophie Haddad, Dmitry Khrichenko, Chandra Sehgal, Daeyeon Lee, and Todd J. Kilbaugh. "Can Ultrasound-Guided Xenon Delivery Provide Neuroprotection in Traumatic Brain Injury?." Neurotrauma Reports 3, no. 1 (2022): 97-104.

Liver and spleen volume and stiffness in patients post-Fontan procedure and patients with ARPKD compared to normal controls

Serai, Suraj D., Mohamed M. Elsingergy, Erum A. Hartung, and Hansel J. Otero. "Liver and spleen volume and stiffness in patients post-Fontan procedure and patients with ARPKD compared to normal controls." Clinical Imaging 89 (2022): 147-154.

Potential benefits of functional magnetic resonance urography (fMRU) over MAG3 renal scan in children with obstructive uropathy

Viteri, Bernarda, Juan S. Calle-Toro, Lance Ballester, Kassa Darge, Susan Furth, Dmitry Khrichenko, Jason Van Batavia, and Hansel Otero. "Potential benefits of functional magnetic resonance urography (fMRU) over MAG3 renal scan in children with obstructive uropathy." Journal of Pediatric Urology 17, no. 5 (2021): 659-e1.

Utility of contrast-enhanced ultrasound for solid mass surveillance and characterization in children with tuberous sclerosis complex: an initial experience

Chan, Joyce PK, Susan J. Back, Seth Vatsky, Juan S. Calle-Toro, Dimitry Khrichenko, Anush Sridharan, Laura Poznick, and Savvas Andronikou. "Utility of contrast-enhanced ultrasound for solid mass surveillance and characterization in children with tuberous sclerosis complex: an initial experience." Pediatric Nephrology 36, no. 7 (2021): 1775-1784.

MRI-Derived Subcutaneous and Visceral Adipose Tissue Reference Values for Children Aged 6 to Under 18 Years

Marunowski, Kacper, Dominik Świętoń, Włodzimierz Bzyl, Małgorzata Grzywińska, Mariusz Kaszubowski, Piotr Bandosz, Dmitry Khrichenko, and Maciej Piskunowicz. "MRI-derived subcutaneous and visceral adipose tissue reference values for children aged 6 to under 18 years." Frontiers in Nutrition: 714.

Novel Computerized Analytic Technique for Quantification of Amniotic Fluid Volume in Fetal MRI

Didier, Ryne A., Dmitry Khrichenko, Christian A. Barrera, Carolina Maya, Ann M. Johnson, Edward R. Oliver, Julie S. Moldenhauer, and Teresa Victoria. "Novel Computerized Analytic Technique for Quantification of Amniotic Fluid Volume in Fetal MRI." American Journal of Roentgenology (2019): W1-W4.

Biexponential R2* Relaxometry for Estimation of Liver Iron Concentration in Children: A Better Fit for High Liver Iron States

Barrera, Christian A., Dmitry Khrichenko, Suraj D. Serai, Helge D. Hartung, David M. Biko, and Hansel J. Otero. "Biexponential R2* Relaxometry for Estimation of Liver Iron Concentration in Children: A Better Fit for High Liver Iron States." Journal of Magnetic Resonance Imaging (2019).

R2 relaxometry based MR imaging for estimation of liver iron content: A comparison between two methods

Calle-Toro, Juan S., Christian A. Barrera, Dmitry Khrichenko, Hansel J. Otero, and Suraj D. Serai. "R2 relaxometry based MR imaging for estimation of liver iron content: A comparison between two methods." Abdominal Radiology (2019): 1-11.

Publications
Contact

Contact

Dmitry Khrichenko

Philadelphia, PA, USA

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