pMRI
Parametric MRI
Parametric MRI (pMRI) is a “spiritual successor” to Functional analysis in MR urography—made simple.
The purpose of this software is to provide access to powerful, fast and easy to use tools for various medical imaging post processing techniques including fMRU, T2/T2* mapping with built in LIC conversion, T1 mapping, 3D region growing, T2* perfusion, DWI, Dual Energy CT, Renal Scintigraphy and others. pMRI fully integrates with PACS and runs on Microsoft Windows. The software is currently in open beta and is available for download in the downloads section. Please use the contact form below if you would like more information.
Features
fMRU
Calculate split function and volumes. Generate enhancement, patlak and excretion curves, histograms, functional maps and much more!
Segmentation
Segment images using various tools, ranging from free-hand to advanced region growing. Threshold based on multiple parameters and more.
DWI Analysis
Calculate ADC based on linear and non-linear exponential fits. Estimate perfusion using bi-exponential modeling. Generate virtual b-values.
T1 Mapping
Generate inversion recovery curves from T1 MOLLI data. Calculate mean T1 values, maps and histograms using non-linear least square fitting.
MAG3
Analyze multi-phase renal scintigraphy studies for split function. Threshold/region grow based on counts and generate various curves and histograms
DICOM Support
Import/export DICOM studies and maintain them in a searchable database for quick and easy access. Anonymize multiple studies with two clicks.
Batch Processing
Save your analysis with one key stroke and analyze multiple cases in bulk after. Copy and paste the results directly into excel, avoiding organizational errors.
T2* Perfusion
Generate dynamic ΔR2* maps and ΔR2* vs time curves and histograms. Calculate CBV values and maps based on a gamma variate fit.
T2/T2* Mapping
Calculate mean T2/T2* values and maps with built in LIC conversion for R2/R2* liver iron data. Includes mono and bi-exponential modeling as well as custom weighted fits.
PACS Integration
Setup and connect to multiple servers. Search, send and receive DICOM images over a network. Integrates with common DICOM networking software.
Histograms
Generate histograms of various parameters. Calculate means, standard deviations, and do Gaussian fits. View dynamic histograms in real time.
3D Rendering
Generate up to 8 independent surfaces per analysis. Rotate the images with the mouse and move the camera around freely in real time!
pMRI
Publications
Diffusion Analysis of Intracranial and Head and Neck Epidermoid and Temporal Bone Cholesteatoma
Fabrício Guimarães Gonçalves, Amirreza Manteghinejad, Zekordavar Rimba, Dmitry Khrichenko, Angela N Viaene and Arastoo Vossough. "Diffusion Analysis of Intracranial and Head and Neck Epidermoid and Temporal Bone Cholesteatoma." American Journal of Neuroradiology (2024).
Gołuch, Małgorzata, Agnieszka Pytlewska, Jędrzej Sarnecki, Paulina Chodnicka, Anna Śliwińska, Łukasz Obrycki, and Elżbieta Jurkiewicz. "Evaluation of differential renal function in children–a comparative study between magnetic resonance urography and dynamic renal scintigraphy." BMC pediatrics 24, no. 1 (2024): 213.
Świętoń, Dominik, Kamil Buczkowski, Piotr Czarniak, Andrzej Gołębiewski, Małgorzata Grzywińska, Mariusz J. Kujawa, Susan J. Back, Maciej Piskunowicz, and Ewa Iżycka-Świeszewska. "Insights into Kidney Dysplasia in Duplex Kidneys: From Radiologic Diagnosis to Histopathologic Understanding." Biomedicines 12, no. 5 (2024): 1126.
Spogis, Jakob, Christoph Katemann, Shuo Zhang, Michael Esser, Ilias Tsiflikas, and Jürgen Schäfer. "Feasibility and Implementation of a 4D Free-Breathing Variable Density Stack-of-Stars Functional Magnetic Resonance Urography in Young Children Without Sedation." Investigative Radiology 59, no. 3 (2024): 271-277.
Magnetic Resonance Urography: A Practical Approach to Preparation, Protocol and Interpretation
Otero, Hansel J., Mohamed M. Elsingergy, and Susan J. Back. "Magnetic resonance urography: a practical approach to preparation, protocol and interpretation." Pediatric Radiology 53, no. 7 (2023): 1391-1404.
Gadolinium-Based Functional MR Urography: From Image Acquisition to Interpretation
Rincon-Escobar, Erika A., Dmitry Khrichenko, and Hansel J. Otero. "Gadolinium-Based Functional MR Urography: From Image Acquisition to Interpretation." In Advanced Clinical MRI of the Kidney: Methods and Protocols, pp. 317-329. Cham: Springer International Publishing, 2023.
Advanced Clinical MRI of the Kidney: Methods and Protocols
Serai, Suraj D., and Kassa Darge, eds. Advanced Clinical MRI of the Kidney: Methods and Protocols. Springer Nature, 2023.
Jenkins, Richard, and Dipalee Durve. "Medical imaging." In Medical Innovation, pp. 219-228. CRC Press, 2023.
Marunowski, Kacper, Dominik Świętoń, Włodzimierz Bzyl, Małgorzata Grzywińska, Piotr Bandosz, Dmitry Khrichenko, and Maciej Piskunowicz. "Reference values for MRI‐derived psoas and paraspinal muscles and macroscopic fat infiltrations in paraspinal muscles in children." Journal of Cachexia, Sarcopenia and Muscle (2022).
Gonçalves, Fabrício Guimarães, Colbey Freeman, Dmitry Khrichenko, and Misun Hwang. "Quantitative Evaluation of Brain Echogenicity in Hypoxic-Ischemic Encephalopathy in Term Neonates Compared with Controls." Ultrasound International Open 8, no. 02 (2022): E43-E52.
Can Automated 3-Dimensional Dixon-Based Methods Be Used in Patients With Liver Iron Overload?
Venkatakrishna, Shyam Sunder B., Hansel J. Otero, Dmitry Khrichenko, and Suraj D. Serai. "Can Automated 3-Dimensional Dixon-Based Methods Be Used in Patients With Liver Iron Overload?." Journal of Computer Assisted Tomography (2022): 10-1097.
Gonçalves, Fabrício Guimarães, Luis Octavio Tierradentro-Garcia, Jorge Du Ub Kim, Alireza Zandifar, Adarsh Ghosh, Angela N. Viaene, Dmitry Khrichenko, Savvas Andronikou, and Arastoo Vossough. "The role of apparent diffusion coefficient histogram metrics for differentiating pediatric medulloblastoma histological variants and molecular groups." Pediatric Radiology (2022): 1-15.
Francavilla, Michael L., Suraj D. Serai, Timothy G. Brandon, David M. Biko, Dmitry Khrichenko, Jie C. Nguyen, Rui Xiao, Nancy A. Chauvin, Liya Gendler, and Pamela F. Weiss. "Feasibility of T2 Mapping of the Sacroiliac Joints in Healthy Control Subjects and Children and Young Adults with Sacroiliitis." ACR open rheumatology 4, no. 1 (2022): 74-82.
Gonçalves, Fabrício Guimarães, Alireza Zandifar, Jorge Du Ub Kim, Luis Octavio Tierradentro-García, Adarsh Ghosh, Dmitry Khrichenko, Savvas Andronikou, and Arastoo Vossough. "Application of Apparent Diffusion Coefficient Histogram Metrics for Differentiation of Pediatric Posterior Fossa Tumors." Clinical Neuroradiology (2022): 1-12.
Rate of Change of Liver Iron Content by MR Imaging Methods: A Comparison Study
Venkatakrishna, Shyam Sunder B., Hansel J. Otero, Adarsh Ghosh, Dmitry Khrichenko, and Suraj D. Serai. "Rate of Change of Liver Iron Content by MR Imaging Methods: A Comparison Study." Tomography 8, no. 5 (2022): 2508-2521.
Can Ultrasound-Guided Xenon Delivery Provide Neuroprotection in Traumatic Brain Injury?
Hwang, Misun, Rajarshi Chattaraj, Anush Sridharan, Samuel S. Shin, Angela N. Viaene, Sophie Haddad, Dmitry Khrichenko, Chandra Sehgal, Daeyeon Lee, and Todd J. Kilbaugh. "Can Ultrasound-Guided Xenon Delivery Provide Neuroprotection in Traumatic Brain Injury?." Neurotrauma Reports 3, no. 1 (2022): 97-104.
Serai, Suraj D., Mohamed M. Elsingergy, Erum A. Hartung, and Hansel J. Otero. "Liver and spleen volume and stiffness in patients post-Fontan procedure and patients with ARPKD compared to normal controls." Clinical Imaging 89 (2022): 147-154.
Viteri, Bernarda, Juan S. Calle-Toro, Lance Ballester, Kassa Darge, Susan Furth, Dmitry Khrichenko, Jason Van Batavia, and Hansel Otero. "Potential benefits of functional magnetic resonance urography (fMRU) over MAG3 renal scan in children with obstructive uropathy." Journal of Pediatric Urology 17, no. 5 (2021): 659-e1.
Chan, Joyce PK, Susan J. Back, Seth Vatsky, Juan S. Calle-Toro, Dimitry Khrichenko, Anush Sridharan, Laura Poznick, and Savvas Andronikou. "Utility of contrast-enhanced ultrasound for solid mass surveillance and characterization in children with tuberous sclerosis complex: an initial experience." Pediatric Nephrology 36, no. 7 (2021): 1775-1784.
Marunowski, Kacper, Dominik Świętoń, Włodzimierz Bzyl, Małgorzata Grzywińska, Mariusz Kaszubowski, Piotr Bandosz, Dmitry Khrichenko, and Maciej Piskunowicz. "MRI-derived subcutaneous and visceral adipose tissue reference values for children aged 6 to under 18 years." Frontiers in Nutrition: 714.
Novel Computerized Analytic Technique for Quantification of Amniotic Fluid Volume in Fetal MRI
Didier, Ryne A., Dmitry Khrichenko, Christian A. Barrera, Carolina Maya, Ann M. Johnson, Edward R. Oliver, Julie S. Moldenhauer, and Teresa Victoria. "Novel Computerized Analytic Technique for Quantification of Amniotic Fluid Volume in Fetal MRI." American Journal of Roentgenology (2019): W1-W4.
Barrera, Christian A., Dmitry Khrichenko, Suraj D. Serai, Helge D. Hartung, David M. Biko, and Hansel J. Otero. "Biexponential R2* Relaxometry for Estimation of Liver Iron Concentration in Children: A Better Fit for High Liver Iron States." Journal of Magnetic Resonance Imaging (2019).
Calle-Toro, Juan S., Christian A. Barrera, Dmitry Khrichenko, Hansel J. Otero, and Suraj D. Serai. "R2 relaxometry based MR imaging for estimation of liver iron content: A comparison between two methods." Abdominal Radiology (2019): 1-11.
